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ID:96 Haemoglobin A1c (HbA1c)
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DescriptionHbA1c was originally introduced as a marker of diabetes severity but in 2011, WHO redesignated the diagnostic criteria for diabetes mellitus. The diagnosis is now based on HbA1c > 48 mmol/mol. If an initial test is greater than 48 mmol/mol, then a repeat sample should be taken within a fortnight to confirm. It should be noted that glucose should still be used to diagnose diabetes mellitus in: 1. ALL symptomatic children and young people. 2. where symptoms suggest type 1 diabetes (any age). 3. where there is a short duration of diabetes symptoms. 4. in any patient who is acutely ill. Please note that HbA1c will be invalid soon after transfusions and may give misleading results in patients with haemoglobinopathies and in patients with iron deficiency anaemia. Note HbA1c is reported in IFCC (mmol/mol) units.
IndicationDiagnosis and monitoring of Diabetes Mellitus
Additional InfoGlucose attatchment to Hb has been used to monitor glycaemic control in the diabetic. Much of the heterogeneity of adult Hb is the result of glycation. Normal Hb is designated as HbA and is made up of 2 alpha and 2 beta protein chains
Concurrent Testsna
Dietary Requirementsna
InterpretationThe HbA1c levels reflect glucose control over a period of 6 - 8 weeks. 42-47 mmol/mol is classed as pre diabetes, > or equal to 48 and <58 is classed as in control diabetic mmol/mol control diabetic, >58 is classed as not in control diabetic. (NICE Guidelines)

DepartmentBlood Sciences
SampleBlood
TubeEDTA (Haem)
Tube Picture
Collection ConditionsA separate EDTA blood sample is required for HbA1c analysis
Min. Vol0.5ml
Freq.Daily

Ref. Range (Male)See Notes
Ref. Range (Female) See Notes
Ref. Range (Paed) See Notes
Ref. Range Notes<42 (42-47 mmol/mol is classed as pre diabetes, > or equal to 48 and <58 is classed as in control diabetic mmol/mol control diabetic, >58 is classed as not in control diabetic. (NICE Guidelines)
Unitsmmol/mol
IP Acute TAT- Not Defined -
IP Routine TAT7 days
GP Acute TAT7 days
GP Routine TAT7 days
Turnround CommentTAT 7 working days. Minimum re-test interval = 28 days (exception re-checking initial result >48 should be repeated within 2 weeks)

Originally edited by : mc. Review due on 19/10/2018 10:57:24. Published By S.Bennett on 19/10/2017 10:57:24.