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ID:952 Heparin Induced Thrombocytopaenia (HIT) Screen
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DescriptionHeparin Induced Thrombocytopenia (HIT) is the development of a thrombocytopenia in patients on heparin therapy. This is an immune mediated disorder in which heparin binds to Platelet Factor 4. These antibodies can bind to the Fc receptor on platelets leading to platelet activation.
IndicationPatients with a "4 T's" score of 4 - 8.
Additional InfoThis test should only be requested after prior discussion with the haematology medical team. This HIT screen acts as a negative predictive indicator for the presence of HIT.
Concurrent Tests
Dietary Requirements
InterpretationResults of less than 1.0 Units/ml are indicative of the absence of HIT. For results exceeding 1.0U/ml there is a possibility of HIT and further confirmatory tests are indicated. A serum sample is required so any positive results can automatically be referred on to Sheffield (for confirmation by specific IgG antibody analysis) without having to recall the patient for re-bleeding.

DepartmentSpecialist Laboratory Medicine
SampleBlood
TubeSerum + Coagulation
Tube Picture
Collection Conditions1x Citrate tube (Blue) filled to line AND 1 x Serum Gel (Gold) sample
Min. VolTo Line
Freq.

Ref. Range (Male)< 1.0
Ref. Range (Female)< 1.0
Ref. Range (Paed)< 1.0
Ref. Range NotesCritical telephone values: All results will be phoned to the coagulation registrar or haematology registrar on call (out of hours)
UnitsU/mL
IP Acute TAT- Contact Laboratory
IP Routine TAT24 hours
GP Acute TAT- Contact Laboratory
GP Routine TAT24 hours
Turnround CommentSpecialist test only requested as part of further investigations by a medical haematologist. Test only available Mon to Fri, 08:00 to 17:00.

Originally edited by : RJAR. Review due on 18/06/2019 10:35:46. Published By RJAR on 18/06/2018 10:35:46.