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ID:912 Orexin (CSF)
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DescriptionInvestigation of narcolepsy and other neurological sleep disturbances. Orexin (also see Hypocretin) is a neurotransmitter that regulates wakefulness and appetite. The most common form of narcolepsy, in which the sufferer briefly loses muscle tone (cataplexy), is caused by a lack of Orexin in the brain.
Indication
Additional InfoN.B. No serum sample required
Concurrent Testsna
Dietary Requirementsna
Interpretation

Department* Not Specified *
SampleCSF
TubePlain Universal
Tube Picture
Collection ConditionsNo restrictions
Min. Vol2mL
Freq.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes Normal: >200 pg/mL; Intermediate: 100-200 pg/mL; Low: <100 pg/mL; Highly suggestive of narcolepsy/cataplexy: <50 pg/mL. Intermediate and low values are occassionally found in patients with other neurological diseases associated with sleep disturbance
Unitspg/mL
IP Acute TATAt least 4 weeks
IP Routine TATAt least 4 weeks
GP Acute TATAt least 4 weeks
GP Routine TATAt least 4 weeks
Turnround CommentSarosh Irani:sarosh.irani@ndcn.ox.ac.uk

Originally edited by : dan carless. Review due on 17/10/2017. Published By dan carless on 17/10/2017.