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ID:905 ADAMTS13 Assay
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DescriptionADAMTS13 cleaves Von Willebrands factor into smaller multimers. A deficiency of inhibition of ADAMTS13 activity leads to very large Von Willebrands multimers being released into the circulation. These activate platelets causing aggregation and the formation of micro-thrombi. The poor prognosis associated with TTP requires early, accurate diagnosis
Indication To investigate Thrombotic Thrombocytopaenic Purpura (TTP)
Additional Info Also known as Von Willebrands cleaving protease
Concurrent TestsCoagulation screen, FBC
Dietary RequirementsNone
InterpretationReported against a normal range

DepartmentSpecialist Coagulation
SampleBlood
TubeCoagulation
Tube Picture
Collection Conditions2 x Citrate tube filled to line please
Min. Vol 1 x properly filled citrate tube
Freq.

Ref. Range (Male)52 - 130
Ref. Range (Female) 52 - 130
Ref. Range (Paed) 52 - 130
Ref. Range Notes
Units%
IP Acute TAT- Contact Laboratory
IP Routine TAT5 days
GP Acute TAT- Contact Laboratory
GP Routine TAT5 days
Turnround CommentThis test is referred to the Royal Hallamshire Hospital, Sheffield

Originally edited by : RJAR. Review due on 12/07/2020 17:06:22. Published By B Dickinson on 12/07/2019 17:06:22.