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ID:900 Bethesda Inhibitor Assay
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DescriptionThis assay quantifies the amount of antibodies to FVIII in Haemophilia A patients
IndicationHaemophilia A patients that are unresponsive to treatment or have a positive mixing study / inhibitor screen. Patients suspected of having an aquired FVIII inhibitor.
Additional InfoThe assays can be adapted to be sensitive to other clotting factors. One Bethesda unit is defined as the amount of antibody that can neutralise 50% of the FVIII in normal plasma when incubated together for 2 hours at 37 C.
Concurrent TestsCoagulation screen, factorr assays
Dietary RequirementsNone
InterpretationReportes in Bethesda units or as absent

DepartmentSpecialist Laboratory Medicine
SampleBlood
TubeCoagulation
Tube Picture
Collection ConditionsAll citrate tubes filled to line please - 2 citrate samples required
Min. Vol0.5ml
Freq.

Ref. Range (Male)NA
Ref. Range (Female)NA
Ref. Range (Paed)NA
Ref. Range NotesCritical telephone values: All new / relapsed positive bethesda assays will be phoned to the appropriate haematology consultant Normal patients have no inhibitor present
UnitsBethesda Units
IP Acute TAT- Contact Laboratory
IP Routine TAT5 days
GP Acute TAT- Contact Laboratory
GP Routine TAT- Contact Laboratory
Turnround CommentSpecialist test only requested as part of an investigation by a medical haematologist. The test may be referred externally in certain circumstances to: Coagulation Laboratory Room H101E, H floor H Floor Royal Hallamshire Hospital Glossop Road Sheffield S10 2JF

Originally edited by : RJAR. Review due on 13/09/2019 15:47:10. Published By RJAR on 13/09/2018 15:47:10.