|Description||A GI tract hormone.
Please note this test is performed by North West London Pathology|
|Indication||Zollinger Ellison syndrome. Recurrent ulcer disease or duodenal ulcer and high gastric acid output.
|Additional Info||Gastrin exists in multiple molecular forms. It originates in the G cells of the gut and is secreted directly into the blood stream. Gastrin effects smooth muscle and the secretory cells of the gut. It stimulates acid secretion and gastric motility. The secretion of gastrin is stimulated by the products of digestion and distension of the antral pouch. Gastrin secretion is inhibited by VIP, glucagon and calcitonin. Gastrin is degraded in the kidney and SI. Plasma gastrin levels are important in the diagnosis of gastrinomas (pancreatic neuroendocrine tumours). Zollinger Ellison Syndrome is caused by a gastrinoma or antral G cell hyperplasia and is charcaterised by peptic ulceration, gastric acid hypersecretion. Other cuases of elevated gastrin include achlorhydria (highest levels seen in pernicious anaemia), post surgert (vagotomy, retained isolated antrum, short gut syndrome), drugs, renal failure and hypercalcaemia.|
|Interpretation||H2 blockers and proton pump inhibitors lead to falsely elevated gastrin. Levels usually > 100 pmol/L in Zollinger Ellison Syndrome but any value > 40 pmol/L is consistent with gastrinoma|
|Collection Conditions||Sample must be fasting > 10 hours. Proton pump inhibitors should be stopped 6 weeks prior to testing and H2-blockers stopped 48 hrs before.
Collect into an EDTA tube. **Must be brought to the lab within 15 min of collection for urgent processing.**|
|Min. Vol||5 mL (3 mL plasma)|
|Freq.||Referred to external laboratory |
|Ref. Range (Male)|
|Ref. Range (Female)|| |
|Ref. Range (Paed)|| |
|Ref. Range Notes||<40|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||3 weeks|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||- Contact Laboratory|
|Turnround Comment||Susan Willams / Paul Bech:email@example.com|
Originally edited by : JHB. Review due on 28/02/2020 13:57:00. Published By Matthew Clifford on 28/02/2019 13:57:00.