|Description|| Creutzfeldt–Jakob disease or CJD is a degenerative neurological disorder (brain disease) that is incurable and invariably fatal. CJD is at times called a human form of mad cow disease, given that bovine spongiform encephalopathy is believed to be the cause of variant Creutzfeldt–Jakob disease in humans.
CJD is the most common among the types of transmissible spongiform encephalopathy found in humans. In CJD, the brain tissue develops holes and takes on a sponge-like texture. This is due to a type of infectious protein called a prion. Prions are misfolded proteins which replicate by converting their properly folded counterparts.|
|Indication||The first symptom of CJD is rapidly progressive dementia, leading to memory loss, personality changes and hallucinations. This is accompanied by physical problems such as speech impairment, jerky movements (myoclonus), balance and coordination dysfunction (ataxia), changes in gait, rigid posture, and seizures. The duration of the disease varies greatly, but sporadic (non-inherited) CJD can be fatal within months or even weeks (Johnson, 1998). In some people, the symptoms can continue for years. In most patients, these symptoms are followed by involuntary movements and the appearance of an atypical diagnostic electroencephalogram tracing. Most victims die 6 months after initial symptoms appear, often of pneumonia due to impaired coughing reflexes. About 15% of patients survive 2 or more years|
|Additional Info||Please contact the Virus laboratory on extension 28750 for further information and details of how to transport the samples|
|Collection Conditions||Please contact the Virology laboratory|
|Ref. Range (Male)|| |
|Ref. Range (Female)|| |
|Ref. Range (Paed)|| |
|Ref. Range Notes|| |
|Units|| - Not Defined -|
|IP Acute TAT||28 days|
|IP Routine TAT||28 days|
|GP Acute TAT||28 days|
|GP Routine TAT||28 days|
|Turnround Comment||Results may be available considerably earlier than stated turnaround time.|
Originally edited by : D Bennett. Review due on 28/06/2017 08:50:38. Published By K Roberts on 28/06/2016 08:50:38.