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ID:81 Anti-ENA Antibodies
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DescriptionAutoantibodies to extractable nuclear antigens (ENAs) are associated with certain connective tissue diseases.
IndicationDiagnosis of SLE, Sjorgen's, Mixed Connective Tissue Disease, Polymyositis, Scleroderma.
Additional InfoAnti-ENA antibody tests are now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser. The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab. For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.
Concurrent Testsna
Dietary Requirementsna
InterpretationAnti- Ro and -La antibodies occur in 30-40% of SLE patients and 60% of patients with Sjogren's syndrome. Anti-Sm antibodies are specific for SLE but are found in only 20-30% of patients (usually non-Caucasian patients). Anti-RNP Ab can be associated with mixed connective tissue disease and with systemic sclerosis. Anto-Scl-70 Ab are associated with systemic sclerosis, and anti-Jo-1 Ab are associated with polymyositis/dermatomyositis. Centromere Ab are associated with limited sclerosis.

DepartmentClinical Immunology
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol2 mL

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesAI unit = Antibody Index With the exception of anti-La and anti-Scl-70 Ab a result of 1AI or above is a positive result. For anti-La and anti-Scl-70 Ab a result of 2.5AI or above is positive.
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA

Originally edited by : JHB. Review due on 14/09/2018 14:17:46. Published By AM on 14/09/2017 14:17:46.