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ID:789 Procollagen peptide type III (P3NP)
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DescriptionPIIINP can be a marker of hepatic fibrosis. Used to monitor hepatic fibrosis, particularly in dermatology patients receiving methotrexate. SERUM SAMPLE REQUIRED (WITH OR WITHOUT SEPARATOR GEL)
IndicationMonitoring for hepatic fibrosis, particularly in dermatology patients receiving methotrexate
Additional InfoPIIINP is the amino terminal peptide of type III procollagen, released from the precursor peptide during the synthesis and deposition of type III collagen. PIIINP in the serum can be derived from the synthesis of new type III collagen or from the degradation of existing type III collagen fibrils. There is evidence that serum PIIINP measurement is an effective non-invasive test for the detection and monitoring of methotrexate-induced liver fibrosis and cirrhosis, and serial measurements may reduce the need for liver biopsy. Dermatology patients with repeated normal levels of PIIINP are very unlikely to have significant liver damage from fibrosis or cirrhosis. The role of PIIINP in rheumatology patients is unclear as it can be falsely elevated in inflammatory arthritis.Need 0.5ml serum.
Concurrent Testsna
Dietary Requirementsna
InterpretationPlease refer to the following guideline: BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists; Rheumatology 2008.

TubeSerum gel or no gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol0.5 Ml

Ref. Range (Male)
Ref. Range (Female)
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Ref. Range Notes
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TAT- Contact Laboratory
Turnround CommentNA

Originally edited by : . Review due on 23/05/2017 08:07:05. Published By Sylvia McLellan on 23/05/2016 08:07:05.