|Description||Anti-double stranded DNA Ab are a highly sensitive and specific diagnostic marker of SLE. They are the most frequently detected autoAb associated with SLE.|
|Indication||Diagnosis and monitoring of SLE.|
|Additional Info||Anti-DNA antibody test is now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser.
The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab.
For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.|
|Concurrent Tests||Anti-nuclear Ab (ANA) screen|
|Interpretation||Positive anti-DNA antibodies are found in 70-90% of patients with SLE and tend to correlate with disease activity. Raised levels may also be seen in a small minority of patients with autoimmune hepatitis. A negative dsDNA Ab does not rule out the diagnosis of SLE.|
|Collection Conditions||No restrictions|
|Min. Vol||2 mL|
|Ref. Range (Male)|
|Ref. Range (Female)|| |
|Ref. Range (Paed)|| |
|Ref. Range Notes||10 IU/ml and above is POSITIVE|
|Units|| - Not Defined -|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||7 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||7 days|
Originally edited by : BD. Review due on 14/09/2018 14:17:28. Published By AM on 14/09/2017 14:17:28.