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ID:75 Anti-DNA antibodies
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DescriptionAnti-double stranded DNA Ab are a highly sensitive and specific diagnostic marker of SLE. They are the most frequently detected autoAb associated with SLE.
IndicationDiagnosis and monitoring of SLE.
Additional InfoAnti-DNA antibody test is now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser. The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab. For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.
Concurrent TestsAnti-nuclear Ab (ANA) screen
Dietary RequirementsNA
InterpretationPositive anti-DNA antibodies are found in 70-90% of patients with SLE and tend to correlate with disease activity. Raised levels may also be seen in a small minority of patients with autoimmune hepatitis. A negative dsDNA Ab does not rule out the diagnosis of SLE.

DepartmentClinical Immunology
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol2 mL

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes10 IU/ml and above is POSITIVE
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround Comment

Originally edited by : BD. Review due on 14/09/2018 14:17:28. Published By AM on 14/09/2017 14:17:28.