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ID:72 Cryoglobulin
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DescriptionCryoglobulins are immunoglobulins which reversibly precipitate in the cold. Type I (monoclonal) cryoglobulins are associated with B-cell lymphoma and myeloma whilst mixed cryoglobulins (type II and III) are associated with infective and inflammatory disorders.
IndicationCryoprecipitates are more commonly of mixed type and are immune complexes causing a vasculitis, synovitis or glomerulaneohritis in association with a connective tissue disorder and certain infections. Consider cryoglobulinaemia in any patient with unexplained vasculitis.
Additional InfoThe requesting doctor should contact Immunology reception (LGI x22117 or SJUH x64579) to inform staff that they wish to take a cryoglobulin sample. Reception staff will prepare an insulated flask containing water warmed to 37oC. An insulated flask will be collected from Clinical Immunology Reception (Old Medical School, LGI) or Transplant Immunology Reception (Gledhow Wing, SJUH) by the requesting doctor or phlebotomist just prior to sample collection. Once the patient has been bled the sample will be immediately transported in the flask back to Reception.
Concurrent TestsComplement C3/4, RF. Igs, SEP
Dietary Requirementsna
InterpretationWhen first identified the cryoglobulin type will be indicated where possible.

DepartmentClinical Immunology
TubeSerum Gel
Tube Picture
Collection ConditionsIt is essential to collect a sample in an Immunology tube, immerse it in a flask of water at 37C and bring to the laboratory asap. Please warn the laboratory of its impending arrival.
Min. Vol4 mL
Freq.As requested

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesQualitative - pos/neg
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT10 days
GP Acute TAT- Contact Laboratory
GP Routine TAT10 days
Turnround CommentSample will be retained for 10days at 4^C to allow the any cryoprecipitate to form.

Originally edited by : BD. Review due on 14/09/2018 14:26:54. Published By AM on 14/09/2017 14:26:54.