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ID:698 Clobazam
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DescriptionClobazam is one of the benzodiazepines. Most commonly used as an oral antiepileptic.
IndicationTherapeutic drug monitoring (TDM)
Additional InfoClobazam has a wide therapeutic window. As tolerance can develop there is no clear relationship between plasma concentration and efficacy. Norclobazam is less potent that clobazam but retains some anti-epileptic activity.
Concurrent Tests
Dietary Requirements
InterpretationNo correlation between either seizure control or toxicity has yet been established, but the majority of patients receiving treatment with conventional doses of clobazam have plasma concentrations below 200 g/L for the parent drug and 2000 g/L for the desmethyl metabolite. Desmethylclobazam has a longer half-life and therefore reaches higher plasma concentration.

DepartmentBiochemistry
SampleBlood
TubeEDTA (Haem)
Tube Picture
Collection ConditionsDo NOT use gel seperator tubes.
Min. Vol1 mL
Freq.Referred to external laboratory

Ref. Range (Male) 0.1 - 0.4 mg/L
Ref. Range (Female) 0.1 - 0.4 mg/L
Ref. Range (Paed)
Ref. Range Notes
Unitsmg/L
IP Acute TAT- Not Defined -
IP Routine TAT- Not Defined -
GP Acute TAT- Not Defined -
GP Routine TAT- Not Defined -
Turnround CommentTurnaround time stated by referral lab: 7 days

Originally edited by : Eleanor McLaughlan. Review due on 22/07/2020 13:47:29. Published By Eleanor McLaughlan on 22/07/2019 13:47:29.