|Indication||Therapeutic drug monitoring (TDM)|
|Interpretation||No correlation between either seizure control or toxicity has yet been established, but the majority of patients receiving treatment with conventional doses of clobazam have plasma concentrations below 200 µg/L for the parent drug and 2000 µg/L for the desmethyl metabolite. Desmethylclobazam has a longer T1/2 and therefore reaches higher plasma concentration.
|Tube||Serum (No Gel)|
|Collection Conditions||Do NOT use gel seperator tubes. Heparin tubes (no gel) and EDTA samples are also acceptable|
|Min. Vol||2 mL|
|Freq.||Referred to external laboratory|
|Ref. Range (Male)|| 0.1 - 0.4 mg/L|
|Ref. Range (Female)|| 0.1 - 0.4 mg/L|
|Ref. Range (Paed)|| |
|Ref. Range Notes||0.1-0.4|
|IP Acute TAT||Refer to Website|
|IP Routine TAT||7 days|
|GP Acute TAT||Refer to Website|
|GP Routine TAT||Refer to Website|
|Turnround Comment||Robert Haddon:HutchingsAD@cardiff.ac.uk|
Originally edited by : . Review due on 22/11/2018 10:24:06. Published By RB on 22/11/2017 10:24:06.