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ID:697 Levetiracetam
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DescriptionAnti-epileptic. It is rapidly absorbed after oral ingestion with 100% bioavailability. Plasma levetiracetam concentrations increase linearly with dose and it is not bound to plasma proteins. The drug’s elimination is primarily renal, but some non-hepatic enzyme dependent metabolism occurs that produces pharmacologically inactive metabolites.
IndicationTherapeutic drug monitoring (TDM) . When non-compliance or toxicity is suspected.
Additional InfoSamples can be takne 6 hours post dose or immediately before the next dose.
Concurrent Testsna
Dietary Requirementsna
InterpretationThe relationship between plasma concentration and clinical effect has not been determined. There is large inter-individual differences between the dose and plasma concentration. Several of the toxic signs of levetiracetam are similar to many of the other anticonvulsant drugs with which it will be prescribed.

DepartmentBiochemistry
SampleBlood
TubeEDTA
Tube Picture
Collection ConditionsSerum gel tube not suitable
Min. Vol2 mL
Freq.Referred to external laboratory

Ref. Range (Male)12 - 46
Ref. Range (Female)12 - 46
Ref. Range (Paed)
Ref. Range Notes
Unitsmg/L
IP Acute TAT1 week
IP Routine TAT1 week
GP Acute TAT1 week
GP Routine TAT1 week
Turnround CommentRobert Haddon:HutchingsAD@cardiff.ac.uk

Originally edited by : EM. Review due on 27/07/2019 11:16:50. Published By on 27/07/2018 11:16:50.