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ID:68 Cortisol
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DescriptionFirst line test for diagnosis of adrenal disorders. Cortisol is subject to a diurnal rhythms. A random cortisol is only useful if it is found to be very high indicating the need for further investigation of Cushing's.
IndicationDiagnosis of Cushing's syndrome, primary (Addison's) and secondary hypoadrenalism. Also monitornig of steroid replacement therapy.
Additional InfoPLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 6 HOURS OF COLLECTION
Concurrent Testsna
Dietary Requirementsna
InterpretationNormal serum cortisol does NOT exclude adrenal insufficiency. A synacthen test is necessary. Raised serum cortisol must be followed up by dynamic function tests.Diurnal rhythm 100-600 @ 0900h. Cushings disease is excluded by 2400 h cortisol <50nmol/L. Short synacthen test: normal reponse is >600nmol/L at 30 mins post administration.

DepartmentBlood Sciences
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL
Freq.Weekdays

Ref. Range (Male)100 - 600
Ref. Range (Female)100-600
Ref. Range (Paed)
Ref. Range Notes100-600 at 09:00 hrs. <50 at 24:00 hrs
Unitsnmol/L
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TATRefer to Website
Turnround CommentNA

Originally edited by : JHB. Review due on 23/05/2017 07:57:03. Published By Sylvia McLellan on 23/05/2016 07:57:03.