|Description||First line test for diagnosis of adrenal disorders. Cortisol is subject to a diurnal rhythms. A random cortisol is only useful if it is found to be very high indicating the need for further investigation of Cushing's.|
|Indication||Diagnosis of Cushing's syndrome, primary (Addison's) and secondary hypoadrenalism. Also monitornig of steroid replacement therapy.|
|Additional Info||PLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 6 HOURS OF COLLECTION|
|Interpretation||Normal serum cortisol does NOT exclude adrenal insufficiency. A synacthen test is necessary. Raised serum cortisol must be followed up by dynamic function tests.Diurnal rhythm 100-600 @ 0900h. Cushings disease is excluded by 2400 h cortisol <50nmol/L.
Short synacthen test: normal reponse is >600nmol/L at 30 mins post administration.|
|Collection Conditions||No restrictions|
|Min. Vol||1 mL|
|Ref. Range (Male)||100 - 600|
|Ref. Range (Female)||100-600|
|Ref. Range (Paed)|| |
|Ref. Range Notes||100-600 at 09:00 hrs. <50 at 24:00 hrs|
|IP Acute TAT||Refer to Website|
|IP Routine TAT||Refer to Website|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||Refer to Website|
Originally edited by : JHB. Review due on 23/05/2017 07:57:03. Published By Sylvia McLellan on 23/05/2016 07:57:03.