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ID:66 Copper
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DescriptionCopper is bound to caeruloplasmin, levels of which are increased in other conditions (see Caeruloplasmin entry). Low plasma levels may be found in Wilson disease and associated with a decrease in caeruloplasmin.
IndicationPatients on TPN, Wilson disease, Menke's syndrome (very rare). Unexplained neutropenia/ anaemia
Additional InfoCopper is bound to caeruloplasmin, levels of which are increased in other conditions (see Caeruloplasmin database entry). Copper is also bound to albumin which is a negative acute phase reactant. Copper deficiency is extremely rare although dietary deficiency has been recorded. Symptoms include anaemia and neutropenia. Patients on TPN may become copper deficient. Menke's syndrome is an extremely rare sex linked recessive disorder characterised by kinky hair, facial features and mental retardation.
Concurrent Testsna
Dietary Requirementsna
InterpretationHigh levels of zinc can also cause the copper to fall, and it is one of the treatments used in Wilson disease.

DepartmentSpecialist Laboratory Medicine
SamplePlasma
TubeTrace Metals
Tube Picture
Collection ConditionsFor paediatric samples 0.5mL heparinised blood would be suitable. Consider checking serum caeruloplasmin (red/yellow tube) in patients <45 years of age, where Wilson Disease is suspected.
Min. Vol1 mL
Freq.Twice Weekly

Ref. Range (Male)11 - 22
Ref. Range (Female)as above
Ref. Range (Paed)
Ref. Range NotesLevels in children under 1 year are lower. Consult with laboratory
Unitsumol/L
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA

Originally edited by : JHB. Review due on 09/04/2019 07:57:43. Published By RB on 09/04/2018 07:57:43.