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ID:65 Complement C4
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DescriptionMeasurement of serum complement C3 and C4 is useful in the diagnosis and monitoring of immune complex disease eg SLE.
IndicationInvestigation of renal/joint/connective tissue disorders (especially SLE). Also recurrent infections (VERY rare).
Additional Info Complement concentrations are acute phase proteins and are therefore increased in inflammatory conditions hence concentrations may be normal, despite complement consumption, in some inflammatory and infective disorders.
Concurrent Testsna
Dietary Requirementsna
InterpretationLow levels of complement are found in eg Renal disease (acute or chronic glomerulanephritis), SLE (levels reflect disease activity as well as being low during active disease), some forms of Vasculitis, Septicaemia (gram negative) and Endocarditis.

DepartmentClinical Immunology
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol2 mL
Freq.Weekdays

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes0.14 - 0.54
Unitsg/L
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentMinimum re-test interval = 90 days

Originally edited by : BD. Review due on 14/09/2018 14:26:40. Published By AM on 14/09/2017 14:26:40.