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ID:61 Creatine Kinase (CK)
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DescriptionA marker of muscle damage. Please note: test can only be added to a sample within 24 hours of collection
IndicationMyocardial infarction, myocarditis, muscle disease (dystrophies, myopathies, myosites, malignant pyrexia).
Additional InfoCARDIAC: In MI CK starts to rise 4 - 8 hours post chest pain and peaks at about 24 hrs. It is unreliable 3 days post pain. The CK-MB fraction may be useful to establish the source of a raised CK. Myocarditis can give a similar enzyme picture to MI. MUSCLE: The largest rises occur in association with Duchenne Muscular dystrophy and acute polymyositis. Muscle trauma e.g fitting, falls in the elderly, IM injections, severe exercise also gice rise to raised CK. Other causes of raised CK includedDrugs/toxic substances (steroids, clofibrate, alcohol, CO poisoning), inflammation (myositis), McArdle's syndrome (during exercise) hypothermia, and malignant hyperpyrexia.
Concurrent Testsna
Dietary Requirementsna
InterpretationPost MI, CK will rise within 4 hrs and peak levels will be seen between 12-24 hrs. Levels will return to normal within 3-4 days.

DepartmentBiochemistry
SampleBlood
TubeSerum or Heparin
Tube Picture
Collection ConditionsUse Gold top (serum gel) tube except for Intensive care units, renal unit, transplant unit, patients on IV heparin (use Green/yellow top tube for these patients).
Min. Vol1 mL
Freq.Daily

Ref. Range (Male)40 - 320
Ref. Range (Female) 25 - 210
Ref. Range (Paed)
Ref. Range Notes
Unitsiu/L
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TATRefer to Website
Turnround CommentNA

Originally edited by : MC. Review due on 21/06/2017 12:02:11. Published By S.BENNETT on 21/06/2016 12:02:11.