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ID:49 Calcium
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DescriptionPart of bone profile. Reported as adjusted calcium (calcium corrected for changes in albumin concentration).
Indication
Additional InfoIn plasma 40% of Ca is protein bound, 10% is inorganic complexes and 50% is free (ionized) Ca. Calcium levels are regulated by PTH. HYPERCALCAEMIA: May be clinically associated with fatigue, anorexia, weight loss, bone pain, nausea, polyuria, mental changes. Renal stones (hyperparathyroidism) and acute pancreatitis may also occur. Causes - most common cause in hospitalised patients is malignancy whereas in outpatients it is primary hyperparathyroidism. Other causes include vitamin D excess, thyrotoxicosis, sarcoidosis, tertiary hyperparathyroidism, PTHrP, lithium treatment, milk alkali syndrome, thiazide diuretics, immobilisation, Pagets, Addisons (rarely), acromegaly (occasionally). Familial hypocalciuric hypercalcaemia is a rare, benign condition that has resulted in unnecessary surgery. HYPOCALCAEMIA: May be asymptomatic or cause tetany, cataracts, depression (or other psychiatric problems). Causes include hypoalbuminaemia and chronic renal disease (no symptoms as the ionised levels are normal). Vitamin D deficiency (malabsorption or lack sunlight), renal failure and hypoparathyroidism (usually surgical). Also magnesium deficiency, acute pancreatitis, blood trasnfusions and during conditions resulting in shock.
Concurrent Testsna
Dietary Requirementsna
InterpretationCalcium levels are corrected for the serum albumin levels below 40 g/L. Report as the Adjusted calcium = calcium + [(40 - alb)*0.025]. Laboratory action limits <1.8 mmol/L and >3.0 mmol/L.

DepartmentBiochemistry
SampleBlood
TubeSerum or Heparin
Tube Picture
Collection ConditionsUse Gold top (serum gel) tube except for Intensive care units, renal unit, transplant unit, patients on IV heparin (use Green/Yellow top tube for these patients). Avoid prolonged venous stasis.
Min. Vol1 mL
Freq.Daily

Ref. Range (Male)2.2 - 2.6 (>4 wks, adjusted)
Ref. Range (Female) 2.2 - 2.6 (>4 wks, adjusted)
Ref. Range (Paed)see below
Ref. Range Notes 2.0 - 2.7 (0 - 4 wks) - total calcium (not adjusted)
Unitsmmol/L
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TATRefer to Website
Turnround CommentMinimum retest interval = 36 hours

Originally edited by : MC. Review due on 21/06/2017 11:55:42. Published By S.Bennett on 21/06/2016 11:55:42.