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ID:386 C3 Nephritic Factor
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DescriptionC3 nephritic factor is an autoantibody to the alternative complement pathway C3 convertase which allows persistent activation of C3 convertase which cleaves and activates C3, leading to a persistant decrease in C3.
IndicationShould be requested in any patient with an unexplained persistently low complement C3 with C4 within the reference range. Associated with Mesangiocapillary glomerulonephritis type II and also partial lipodystrophy (sparing the lower limbs).
Additional Info
Concurrent Testsna
Dietary Requirementsna
InterpretationIf positive in patients with renal disease it strongly suggests membranoproliferative glomerular nephritis.

DepartmentClinical Immunology
SampleBlood
TubeSerum Gel
Tube Picture
Collection Conditions
Min. Vol2 mL
Freq.

Ref. Range (Male)See note
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesNegative or positive.
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT10 days
GP Acute TAT- Contact Laboratory
GP Routine TAT10 days
Turnround CommentTurn around time provided by the referral laboratory. Please allow additional time for sample dispatch and return of results.

Originally edited by : BD. Review due on 14/09/2018 14:24:31. Published By AM on 14/09/2017 14:24:31.