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ID:35 Bence Jones Protein
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DescriptionWhen immunoglobulins are synthesised more light chains than heavy chains are produced and free light chains are secreted into the plasma along with intact immunoglobulin. Bence Jones protein is monoclonal immunoglobulin light chain protein. BJP (monoclonal light chains) and polyclonal immunoglobulin light chains are metabolized by the kidney by glomerular filtration, proximal renal tubular absorption and catabolism within the renal tubular cells. About 0.5g/day of free light chain is secreted into serum in a healthy subject. The kidney actually can reabsorb 10-30g/day of free light chain so in a healthy individual no free light chain passes through the kidney and into urine. When there is increased synthesis of immunoglobulins (polyclonal or monoclonal) and when the tubular absorption is saturated, filtered free light chain are excreted into the urine and can be detected using urine protein electrophoresis.
IndicationInvestigation of myeloma.
Additional InfoUrine is screened for BJP by electrophoresis and any BJP thought to be present is typed by immunofixation. It is important to test both blood and urine in the investigation of Multiple Myeloma.
Concurrent TestsSerum electrophoresis
Dietary Requirementsna
InterpretationThe presence of significant amounts of Bence Jones Proteinuria are indicative of malignant B cell proliferation. Small amounts may occur with benign B cell proliferation, or transiently in viral infection or following bone marrow transplantation.

DepartmentClinical Immunology
TubePlain Universal
Tube Picture
Collection ConditionsPlease send in addition an immunology (red/yellow) blood sample for serum protein electrophoresis.
Min. Vol10 mL

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notesnegative/positive
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA

Originally edited by : BD. Review due on 10/09/2015 14:50:49. Published By AM on 10/09/2014 14:50:49.