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ID:341 Free fatty acids and B-hydroxybutyrate
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DescriptionUsed in the investigation of ketolytic defects, and may be useful in the diagnosis of hyperinsulinism or fat oxidation defects. 3-hydroxybutyrate is one of three ketone bodies generated from free fatty acids via ketogenesis.
Indication? Hyperinsulinism, ? Fat oxidation defects (e.g. MCADD), ? Ketolytic defects (e.g. beta ketothiolase deficiency), ketoacidotic states (e.g. alcoholic).
Additional InfoFor ?hyperinsulism and fat oxidation defects the plasma glucose should be less than 2.5mmol/L for analysis to be valid. For ?ketolytic defect investigations, the test should be performed whatever the glucose. Sometimes used in investigation of various ketoacidotic states.
Concurrent TestsFree fatty acids and beta-hydroxybutyrate are both analysed on the sample.
Dietary Requirements
InterpretationFor hyperinsulism, fat oxidation defects and ketolytic defects refer to Paediatric Biochemist at SJUH (ext 64256).

DepartmentBiochemistry
SamplePlasma
TubeFluoride
Tube Picture
Collection ConditionsMUST BE FLUORIDE OXALATE BLOOD.
Min. Vol0.2 mL plasma
Freq.Referred to external laboratory

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesFree fatty acids: 0.1 - 0.6 mmol/L Beta-hydroxybutyrate: < 0.4 mmol/L Results will be reported with an interpretive comment.
Unitsmmol/L
IP Acute TAT- Not Defined -
IP Routine TAT- Not Defined -
GP Acute TAT- Not Defined -
GP Routine TAT- Not Defined -
Turnround CommentTurnaround time stated by referral lab: 5 days

Originally edited by : Eleanor McLaughlan. Review due on 26/07/2020 11:02:52. Published By RB on 26/07/2019 11:02:52.