|Description||Porphobilinogen (PBG) is a pyrrole involved in porphyrin metabolism. It is generated by aminolevulinate (ALA) and the enzyme ALA dehydratase. PBG is then converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase.|
|Indication||Investigation of suspected acute porphyria and acute abdomen of unknown cause.
|Additional Info||For acute porphyrias collect samples when patients are symptomatic. Contact Dr JH Barth (via switchboard) or Dr M Henderson/Tim Degg ext 66861 or x66063. If urgent analysis is required please contact the duty biochemist or on-call duty consultant (via switchboard).|
|Interpretation||An increased PBG excretion is diagnostic of acute porphyria. The specific diagnosis will require further tests (see additional info).|
|Department||Specialist Laboratory Medicine|
|Collection Conditions||Plain random urine. Protect from light. Envelope or black polythene/silver foil will do. Do not discard if not protected from light just comment on form.|
|Min. Vol||10 mL|
|Ref. Range (Male)|| <0.9 umol/mmol creat|
|Ref. Range (Female)||<0.9 umol/mmol creat|
|Ref. Range (Paed)|| <0.9 umol/mmol creat|
|Ref. Range Notes|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||14 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||14 days|
Originally edited by : . Review due on 04/07/2019 08:34:07. Published By RB on 04/07/2018 08:34:07.