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ID:326 Hydroxyindole Acetic Acid (5-HIAA - plasma)
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DescriptionCarcinoid disease is characterised by tumours of the argentaffin cells which produce excessive amounts of serotonin. The serotonin is usually rapidly metabolised by the liver to 5-hydroxyindoleacetic acid which is excreted via the kidneys. However in mid gut tumours with liver metastases, or in foregut tumours where the serotonin drains directly into the systemic circulation, the serotonin can cause flushing, diarrhoea, wheezing and heart disease - the so called 'carcinoid syndrome'.
IndicationUsed in the investigation of carcinoid disease.
Additional InfoFasting sample required (all serotonin containing foods should have been avoided for at least 12 hrs prior to sample collection).
Concurrent Testsna
Dietary Requirementsna
InterpretationRaised levels may be indicative of carcinoid disease.

DepartmentSpecialist Laboratory Medicine
SampleBlood
TubeHeparin
Tube Picture
Collection Conditions"Overnight fast - avoid serotonin containing foods day before blood collection i.e. bananas, walnuts, pineapples, tomatoes, plums, avocado. Collect into Heparin Tube (WITHOUT GEL). For referral labs: if sample is not sent within 48hrs of collection freeze before sending in routine first class post. Please indicate on the request form that the sample has been frozen.
Min. Vol1 mL
Freq.fortnightly

Ref. Range (Male)27-70 nmol/L
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesClinical Cut-off 118nmol/L
Unitsnmol/L
IP Acute TAT- Contact Laboratory
IP Routine TAT20 days
GP Acute TAT- Contact Laboratory
GP Routine TAT20 days
Turnround CommentNA

Originally edited by : . Review due on 15/04/2020 17:08:53. Published By RB on 15/04/2019 17:08:53.