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ID:281 Lupus Anticoagulant
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DescriptionLupus anticoagulant is a heterogenous group of auto antibodies, usually directed at phospholipids. The presence of lupus anticoagulants is generally accompanied by a raised APTT but the physiological effect is an increase in the risk of thrombosis. A Lupus anticoagulant screen consists of a coagulation screen including a second APTT reagent, a Russells viper venom time and an anticardiolipin assay.
Indication1). Investigation of a raised APTT. 2). Investigation of a thrombotic event. 3). Investigation of recurrent miscarraige.
Additional InfoTesting CANNOT be performed if: 1). The patient is on unfractionated heparin. 2). The patient is on warfarin. All positive screens require repeat in 12 weeks to demonstrate continuity.
Concurrent TestsIncludes APTT (Actin FS) APTT-SP (with correction) and dRVVT (with correction)
Dietary RequirementsNone
InterpretationPositive or Negative

DepartmentSpecialist Laboratory Medicine
SampleBlood
TubeCoagulation
Tube Picture
Collection Conditions3 Tubes required - 2 x citrate & 1 x serum (all citrate tubes must be filled to the line).
Min. Vol
Freq.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes
UnitsPositive/Negative
IP Acute TAT- Contact Laboratory
IP Routine TAT- Contact Laboratory
GP Acute TAT- Contact Laboratory
GP Routine TAT- Contact Laboratory
Turnround Comment

Originally edited by : RJAR. Review due on 07/11/2019 14:32:44. Published By RJAR on 07/11/2018 14:32:44.