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ID:268 Zinc Protoporphyrin (ZPP)
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DescriptionZinc protoporphyrin (ZPP) is a compound found in red blood cells when haem production is inhibited by lead and/or by lack of iron.
IndicationMonitoring lead toxicity. Occasionally for investigation of anaemia.
Additional Info
Concurrent Testsna
Dietary Requirementsna
InterpretationRaised with lead toxicity and iron deficiency anaemia

DepartmentSpecialist Laboratory Medicine
SampleBlood
TubeEDTA (Haem)
Tube Picture
Collection ConditionsAlternative tube is the heparin tube, but it is less stable than EDTA if delayed in sending to the laboratory.
Min. Vol0.5 mL
Freq.2x per week

Ref. Range (Male)5 - 55 ug/dL
Ref. Range (Female) 5 - 55 ug/dL
Ref. Range (Paed)
Ref. Range NotesIncreasingly, the ZPP/Hb ratio is requested. In the non exposed population the value is less than 2.0, and in the lead exposed population the level is acceptable up to less than 20.0ug/g.
Unitsug/dL
IP Acute TAT- Contact Laboratory
IP Routine TAT6 days
GP Acute TAT- Contact Laboratory
GP Routine TAT6 days
Turnround CommentNA

Originally edited by : AK. Review due on 09/04/2019 07:57:15. Published By RB on 09/04/2018 07:57:15.