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ID:264 Antithrombin
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DescriptionAntithrombin is a natural occurring inhibitor for normal blood coagulation. Originally termed Antithrombin III, as the name suggests its major effect is by inactivating Thrombin in the coagulation cascade. In the presence of Heparin the rate of Thrombin inactivation is increased several thousand fold.
IndicationInvestigation of hereditary Thrombotic disorders or for the monitoring of Antithrombin levels
Additional InfoUsually requested as part of a thrombophilia screen. Antithrombin can be reduced in patients treated with L-Aspariginase.
Concurrent TestsProtein S, Protein C, FV Leiden mutation, FII prothrombin mutation, clotting screen
Dietary RequirementsNone
InterpretationDecreased levels of Antithrombin are linked with an increased risk of thrombosis

DepartmentSpecialist Coagulation
SampleBlood
TubeCoagulation
Tube Picture
Collection ConditionsFill to the Line. 1 x Citrate sample required
Min. Vol1 Citrate tube filled to line
Freq.Weekdays

Ref. Range (Male)0.80 - 1.20
Ref. Range (Female)0.80 - 1.20
Ref. Range (Paed) 0.80 - 1.20
Ref. Range Notes
Unitsiu/mL
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNot available 24/7 without prior arrangement with the Haematology Consultant

Originally edited by : RJAR. Review due on 12/07/2020 16:54:48. Published By Brad Dickinson on 12/07/2019 16:54:48.