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ID:250 Myositis associated autoantibodies
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DescriptionIdiopathic inflammatory myopahies are an inflammatory disease of skeletal muscles. These myopathies can be divided into polymyositis, dermatomyositis, idiopathic myositis, anti-synthetase syndrome and overlap syndrome.
IndicationDermatomyositis, Polymyositis, idiopathic myositis, anti-synthetase syndrome, overlapping syndrome
Additional InfoThis assay detects autoantibodies to 11 different myositis associated antigens: Jo-1, Mi-2, Ku, PM-Scl100, PM-Scl75, SRP (signal recognition particle), PL-7, PL-12, EJ. OJ and Ro-52.
Concurrent TestsANA
Dietary Requirementsna
InterpretationAnti-Jo-1 Ab are found in polymyositis, often occur simultaneously in autoimmune diseases such as SLE, systemic sclerosis or interstitial lung fibrosis. Mi-2 Ab are highly specific for dermatomyositis. Anti- Jo-1, PL-7, PL-12 EJ and OJ antibodies are associated with anti-synthetase syndrome. Anti-SRP Ab is a marker for immune-mediated necrotising myopathy. Anti-PM-Scl 75 and 100 Ab are associated with overlap syndrome which manifests as a combination of polymyositis, dermatomyoitis and systemic sclerosis symptoms. Anti-Ro52 Ab are not associated with a specific disease, but can be found in both autoimmune and infectious diseases.

DepartmentClinical Immunology
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsStricktly, only available following discussion with Clinical Immunology
Min. Vol5ml
Freq.Weekdays

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesPositive/Negative
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT14 days
GP Acute TAT- Contact Laboratory
GP Routine TAT14 days
Turnround CommentNA

Originally edited by : Anna McHugh. Review due on 26/09/2019 11:31:15. Published By AM on 26/09/2018 11:31:15.