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ID:245 Cold Agglutinins
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DescriptionUsed to demonstrate the presence of cold reacting autoantibodies. If antibodies demonstrated, a full thermal range test is performed. Antibodies detected are usually of the Ii blood group system, are IgM in class, are competent at complement activation but do not cause red cell lysis.
IndicationCold Haemagglutinin Disease (CHAD), Raynauds syndrome, mycoplasma pneumoniae, secondary cold autoimmune haemolytic anaemia.
Additional InfoThis test is now provided by the National Blood Service Reference Laboratory and MUST be requested by a consultant.
Concurrent TestsDirect Coombs Test, Full Thermal Range.
Dietary Requirements

DepartmentBlood Transfusion
TubeEDTA (Crossmatch)
Tube Picture
Collection Conditions***Sample must arrive in the laboratory at 37 degrees centigrade.*** Handwritten sample to include full name, DOB and hospital / NHS / PAS number.
Min. Vol6 mL

Ref. Range (Male)Neat to 1 in 32 @ 4 C.
Ref. Range (Female)Neat to 1 in 32 @ 4 C.
Ref. Range (Paed) Neat to 1 in 32 @ 4 C.
Ref. Range Notes
IP Acute TAT- Contact Laboratory
IP Routine TAT- Contact Laboratory
GP Acute TAT- Not Available -
GP Routine TAT- Not Available -
Turnround CommentConsultant only request

Originally edited by : RJAR. Review due on 03/11/2018 14:22:15. Published By RJAR on 03/11/2017 14:22:15.