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ID:226 Anti-Neutrophil Cytoplasmic Antibodies (ANCA)
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DescriptionPositive ANCA is associated with small vessel vasculitis.
IndicationWegner's Granulomatosis, Microscopic Polyarteritis, Churg-Strauss syndrome.
Additional InfoTwo patterns are identifed by indirect immunofluroescence (IIF) - cytoplasmic (C-ANCA) and perinuclear (P-ANCA). Samples with a P- or C- ANCA by IIF will have anti- MPO and -PR3 antibodies quantified for confirmation. Levels of may also MPO/PR3 also correlate with disease activity.
Concurrent Testsna
Dietary Requirementsna
InterpretationP-ANCA with anti-MPO are found in approximately 70% of patients with Churg-Strauss and Microscopic Polyarteritis. C-ANCA/anti-PR3 are found in approximately 85% of patients with Wegener's. Patients with rheumatoid arthritis, SLE, PSC and ulcerative colits may also have a positive ANCA by IIF but will be negaiive for anti-MPO and PR3 Ab,

DepartmentClinical Immunology
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL

Ref. Range (Male)See notes.
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesANCA immunofluorescence = pos/neg. MPO/PR3 antibodies: 1AI and above is Positive (AI = antibody index)
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentMinimum re-test interval = 14 days

Originally edited by : BD. Review due on 14/09/2018 14:19:00. Published By AM on 14/09/2017 14:19:00.