Trust Homepage > Pathology Homepage

Test and Tubes Database
ID:226 Anti-Neutrophil Cytoplasmic Antibodies (ANCA)
Search Links: General Info : Protocols : LabTestsOnline

DescriptionPositive ANCA is associated with small vessel vasculitis.
IndicationWegner's Granulomatosis, Microscopic Polyarteritis, Churg-Strauss syndrome.
Additional InfoTwo patterns are identifed by indirect immunofluroescence (IIF) - cytoplasmic (C-ANCA) and perinuclear (P-ANCA). Samples with a P- or C- ANCA by IIF will have anti- MPO and -PR3 antibodies quantified for confirmation. Levels of may also MPO/PR3 also correlate with disease activity.
Concurrent Testsna
Dietary Requirementsna
InterpretationP-ANCA with anti-MPO are found in approximately 70% of patients with Churg-Strauss and Microscopic Polyarteritis. C-ANCA/anti-PR3 are found in approximately 85% of patients with Wegener's. Patients with rheumatoid arthritis, SLE, PSC and ulcerative colits may also have a positive ANCA by IIF but will be negaiive for anti-MPO and PR3 Ab,

DepartmentClinical Immunology
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL
Freq.Weekdays

Ref. Range (Male)See notes.
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesANCA immunofluorescence = pos/neg. MPO/PR3 antibodies: 1AI and above is Positive (AI = antibody index)
Units - Not Defined -
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentMinimum re-test interval = 14 days

Originally edited by : BD. Review due on 14/09/2018 14:19:00. Published By AM on 14/09/2017 14:19:00.