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ID:214 Valproate
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DescriptionValproate is used in the treatment of absence seizures. It inhibits the enzymes gamma-aminobutyric acid transaminas (GABA) which results in an increased concentration of GABA in the brain. GABA is an inhibitor of pre and post synaptic discharges in the CNS.
IndicationTherapeutic Drug Monitoring.
Additional InfoFor an adult on a single dose of valproate the half life is 16 hrs but for an adult on chronic therapy the half life is only 12 hrs. PLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 8 HOURS OF COLLECTION
Concurrent Testsna
Dietary Requirementsna
InterpretationPlasma concentration does NOT relate to anticonvulsant activity and their measurement can only be used as a measure of compliance. 90 - 95% of drug is protein bound hence low albumin levels and hepatic disease can increase levels of drug.

DepartmentBiochemistry
SampleBlood
TubeSerum or Heparin
Tube Picture
Collection ConditionsUse gold top (serum gel) tube except for Intensive care units, renal unit, transplant unit, patients on IV heparin (use Green/yellow top tube for these patients).
Min. Vol1 mL
Freq.Daily

Ref. Range (Male)See note
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesUsed only to check compliance. NOTE: Reporting units changed from mmol/L to mg/L May 1, 2007
Unitsmg/L
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TATRefer to Website
Turnround CommentNA

Originally edited by : MC. Review due on 24/05/2017 08:02:29. Published By Sylvia Mclellan on 24/05/2016 08:02:29.