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ID:20 Amiodarone
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DescriptionAmiodarone is an iodine-containing anti-arrhythmic drug which can affect thyroid function tests. Contact Duty Biochemist to discuss availability of this measurement.
IndicationInvestigation of toxicity. Anti-arrhythmic drug used for atrial fibrillation.
Additional InfoAmiodarone has a similar structure to that of thyroid hormones and interferes in the peripheral conversion of T4 to T3. Resulting T4 levels may be high with a low T3 and an increase in rT3. TSH levels may be raised. Furthermore the iodine content of amiodarone can itself cause a hyperthyroid state although this is less common. Basal TFTs should ideally be checked prior to initiation of amiodarone therapy. Assessment of thyroid function once amiodarone therapy has started should be based upon careful clinical examination.
Concurrent Tests
Dietary Requirements
InterpretationHalf life >50 days.

DepartmentBiochemistry
SampleBlood
TubeEDTA (Haem)
Tube Picture
Collection ConditionsGel-separator tubes cannot be used. Take sample just before next dose.
Min. Vol2 mL
Freq.Referred to external laboratory

Ref. Range (Male)See note
Ref. Range (Female) See note
Ref. Range (Paed)
Ref. Range Notes0.5-2.0 mg/L when on 100-500 mg/day. Toxicity >3 mg/L
Unitsmg/L
IP Acute TAT- Not Defined -
IP Routine TAT- Not Defined -
GP Acute TAT- Not Defined -
GP Routine TAT- Not Defined -
Turnround CommentReferral lab stated turnaround time: 7 days

Originally edited by : JHB. Review due on 19/07/2020 12:35:16. Published By Eleanor McLaughlan on 19/07/2019 12:35:16.