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ID:198 Thyroglobulin & antibodies
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DescriptionThyroglobulin is a binding protein for thyroid hormones within the thyroid gland matrix. Thyroglobulin antibodies are measured at the same time to evaluate if any assay interference is present.
IndicationThyroglobulin is useful as a tumour marker for thyroid cancer. It does not have any diagnostic utility in other thyroid diseases.
Additional InfoThyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood.
Concurrent Testsna
Dietary Requirementsna
InterpretationA serum Tg of <0.1 ug/L while on suppressive levothyroxine therapy, has a negative predictive value for recurrent or persistent thyroid cancer of >98%. In selected patients (eg low risk cases) a serum Tg <0.1 may obviate the need for assessing serum Tg under TSH stimulation. Thyroglobulin concentrations are unstable after surgery and radiotherapy. It is recommended to wait 6 to 8 weeks after surgery and 3 months after radioiodine therapy.

DepartmentBlood Sciences
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes
IP Acute TAT- Contact Laboratory
IP Routine TAT2 weeks
GP Acute TAT- Contact Laboratory
GP Routine TAT2 weeks
Turnround CommentMinimum re-test interval = 14 days

Originally edited by : JHB. Review due on 19/02/2019 11:43:44. Published By MPC on 19/02/2018 11:43:44.