|Description||Thyroglobulin is a binding protein for thyroid hormones within the thyroid gland matrix. Thyroglobulin antibodies are measured at the same time to evaluate if any assay interference is present.|
|Indication||Thyroglobulin is useful as a tumour marker for thyroid cancer. It does not have any diagnostic utility in other thyroid diseases.
|Additional Info||Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood.|
|Interpretation||A serum Tg of <0.1 ug/L while on suppressive levothyroxine therapy, has a negative predictive value for recurrent or persistent thyroid cancer of >98%. In selected patients (eg low risk cases) a serum Tg <0.1 may obviate the need for assessing serum Tg under TSH stimulation.
Thyroglobulin concentrations are unstable after surgery and radiotherapy. It is recommended to wait 6 to 8 weeks after surgery and 3 months after radioiodine therapy.|
|Collection Conditions||No restrictions|
|Min. Vol||1 mL|
|Ref. Range (Male)|
|Ref. Range (Female)|| |
|Ref. Range (Paed)|| |
|Ref. Range Notes|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||2 weeks|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||2 weeks|
|Turnround Comment||Minimum re-test interval = 14 days|
Originally edited by : JHB. Review due on 19/02/2019 11:43:44. Published By MPC on 19/02/2018 11:43:44.