|Description||A fetal equivalent of albumin produced predominantly in the liver.|
|Indication||Raised AFP may be seen in hepatocellular carcinoma, hepatoblastoma and germ cell tumours, micronodular cirrhosis and metabolic liver disease. AFP (if produced) is also used for monitoring treatment.
|Additional Info|| PLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 8 HOURS OF COLLECTION|
|Interpretation||Raised: Hepatic carcinoma, hepatitis, gonadal teratoma, pregnancy. LIVER DISEASE: 80% of hepatocellular carcinoma and nearly 100% of hepatoblastomas have AFP > 500 kU/L. AFP < 500 may be seen in non-neoplastic disease. GONADAL TERATOMAS: AFP is measured with HCG to improve sensitivity of detection. 90% of seminomatous malignant germ cell tumours express either AFP or HCG. More than 80% of seminomas express either HCG or placental ALP. OTHER MALIGNANCIES: Tumours of the upper GI tract and liver metastases have also been associated with increased AFP.
|Collection Conditions||No restrictions|
|Min. Vol||1 mL|
|Ref. Range (Male)||<7 kU/L|
|Ref. Range (Female)||<7 kU/L (non - pregnant)|
|Ref. Range (Paed)|| |
|Ref. Range Notes||Concentrations up to 20 kU/L seen in the elderly. Very high at birth (150,000 kU/L) - may take up to 1 yr before decreasing to adult reference range.
|IP Acute TAT||Refer to Website|
|IP Routine TAT||Refer to Website|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||Refer to Website|
|Turnround Comment||Minimum re-test interval = 7 days|
Originally edited by : JHB. Review due on 15/08/2018 17:12:26. Published By Sylvia McLellan on 15/08/2017 17:12:26.