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ID:17 Alpha Fetoprotein (AFP)
Search Links: General Info : Protocols : LabTestsOnline

DescriptionA fetal equivalent of albumin produced predominantly in the liver.
IndicationRaised AFP may be seen in hepatocellular carcinoma, hepatoblastoma and germ cell tumours, micronodular cirrhosis and metabolic liver disease. AFP (if produced) is also used for monitoring treatment.
Additional Info PLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 8 HOURS OF COLLECTION
Concurrent Testsna
Dietary Requirementsna
InterpretationRaised: Hepatic carcinoma, hepatitis, gonadal teratoma, pregnancy. LIVER DISEASE: 80% of hepatocellular carcinoma and nearly 100% of hepatoblastomas have AFP > 500 kU/L. AFP < 500 may be seen in non-neoplastic disease. GONADAL TERATOMAS: AFP is measured with HCG to improve sensitivity of detection. 90% of seminomatous malignant germ cell tumours express either AFP or HCG. More than 80% of seminomas express either HCG or placental ALP. OTHER MALIGNANCIES: Tumours of the upper GI tract and liver metastases have also been associated with increased AFP.

DepartmentBiochemistry
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL
Freq.Daily

Ref. Range (Male)<7 kU/L
Ref. Range (Female)<7 kU/L (non - pregnant)
Ref. Range (Paed)
Ref. Range NotesConcentrations up to 20 kU/L seen in the elderly. Very high at birth (150,000 kU/L) - may take up to 1 yr before decreasing to adult reference range.
Unitsku/L
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TATRefer to Website
Turnround CommentMinimum re-test interval = 7 days

Originally edited by : JHB. Review due on 15/08/2018 17:12:26. Published By Sylvia McLellan on 15/08/2017 17:12:26.