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ID:169 Prostate Specific Antigen (PSA)
Search Links: General Info : Protocols : LabTestsOnline

DescriptionA coagulase secreted in semen and synthsised in the prostate. PLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 8 HOURS OF COLLECTION
IndicationInvestigation for prostatic carcinoma. PSA can also be used in the clinical staging of the disease and follow-up.
Additional InfoPSA is not considered suitable for screening the general population for disease but men over 50 are able to request the test after discussion with their GP. PSA measurement should be followed up by a DRE. PSA increases with clinical disease stage: PSA >50 ug/L is indicative of metastatic disease with >100 ug/L suggesting bony metastases. PSA is also useful for monitoring treatment of prostatic carcinoma. It is useful to measure PSA post prostatectomy with elevated concentrations being indicative of residual disease. It is also useful for predicting tumour recurrence months before any clinical signs. False negative PSA results are seen in 9% cancer patients. The minimum repeat interval for PSA is one month. PSA can be increased following DRE, UTI etc. For more information see: http://www.pathology.leedsth.nhs.uk/pathology/Portals/0/PDFs/BP-2013-05.pdf.
Concurrent Testsna
Dietary Requirementsna
InterpretationIf PSA is >3 ug/L in patients less than 70 years of age presenting to primary care with symptoms suggestive of prostate cancer they should be referred for urological opinion. Note false negative results can also be obtained.

DepartmentBiochemistry
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsOnly measured in males. NA
Min. Vol1 mL
Freq.Daily

Ref. Range (Male)Age related, see comment
Ref. Range (Female)NA
Ref. Range (Paed)
Ref. Range Notes50-59 yrs: <3.0 ug/L, 60-69 yrs: <4.0 ug/L, >70 yrs: <5.0 ug/L Ref: Prostate Cancer Risk Management Programme.
Unitsug/L
IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TATRefer to Website
GP Routine TATRefer to Website
Turnround CommentNA

Originally edited by : JHB. Review due on 27/10/2014 16:39:12. Published By SYLVIA BENNETT on 27/10/2013 16:39:12.