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ID:16 Alpha-1-Antitrypsin (AAT)
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DescriptionMeasurement of alpha-1 antitrypsin is useful in the investigation of emphysema and unexplained liver disease in adults. In paediatric practice, alpha-1 antitrypsin deficiency may be associated with neonatal jaundice.
IndicationDeficiency leads to chronic obstructive airways disease, emphysema, neonatal/juvenile liver disease.
Additional InfoSamples with an AAT concentration of 0.9g/L or below will undergo phenotypic analysis by isoelectric focusing to determine if the patient has one or more (heterozygosity or homozygosity) AAT deficiency alleles. Users will be asked to contact the lab if alpha1-antitrypsin levels are borderline to clarify if phenotyping is required. Note, AAT levels may be within normal range in paediatric patients, therefore if there is a storng suspicion of AAT deficiency AAT phenotyping should also be performed.
Concurrent Testsna
Dietary Requirementsna
InterpretationNOTE Inflammatory conditions may mask deficiency as AAT is an acute phase reactant. Increased levels also occur in malignancy, pregnancy and those taking exogenous oestrogens.

DepartmentClinical Immunology
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL
Freq.Weekdays

Ref. Range (Male)1.1 - 2.1 (Adult)
Ref. Range (Female)1.1 - 2.1 (Adult)
Ref. Range (Paed)
Ref. Range NotesDay 1 to 26 weeks = 0.9-2.2; 26 weeks to 1 years = 0.8-1.8; 1 years to 5 years= 1.1-2; 5 years to 10 years = 1.1-2.2; 10 years to 15 years = 1.4-2.3; 15 years to adult= 1.2-2
Unitsg/L
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA

Originally edited by : BD. Review due on 14/09/2018 14:15:33. Published By AM on 14/09/2017 14:15:33.