|Description||Anti-mitochondrial antibodies are part of an autoantibody screen which includes gastric parietal cell antibodies, liver kidney microsomal antibodies and smooth muscle antibodies that can be detected using mouse liver, kidney and stomach multiblock slides.|
|Indication||Primary Biliary Cirrhosis (PBC)|
|Additional Info||Multiple anti-mitochondrial patterns are identifiable however the M2 pattern is considered pathognomic of Primary Biliary Cirrhosis (PBC). If an unusual/atypical immunofluorescence pattern is detected immunoblotting is performed for confirmation of anti-M2 antibody.
For all new patients with a positive anti-mitochondrial autoantibody the M2-AMA pattern will be confirmed by the liver immunoblot screen.|
|Interpretation||Positive AMA results are titred. For new positive patients only, the M2-AMA pattern is confirmed by Liver Immunoblot.
Anti-Mitochondrial Antibodies (AMA) are a highly sensitive and specific marker for Primary Biliary Cirrhosis (PBC). 95% of patients with PBC have a positive AMA.
Also note they can be seen in other autoimmune conditions such as rheumatoid arthritis, systemic sclerosis and chronic liver disease.|
|Collection Conditions||No restrictions|
|Min. Vol||5 mL|
|Ref. Range (Male)|
|Ref. Range (Female)|
|Ref. Range (Paed)|
|Ref. Range Notes||Positive samples are titred.|
|Units|| - Not Defined -|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||7 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||7 days|
Originally edited by : JHB. Review due on 14/09/2018 14:30:42. Published By AM on 14/09/2017 14:30:42.