|Description||There are three main immunoglobulin isotypes measured by the Immunology laboratory - IgG, IgA and IgM.|
|Indication||The main indication for testing immunoglobulin levels is the investigation of immunodeficiency states.
Other indications are lymphoproliferative diseases however a Myeloma screen requires serum and urine electrophoresis.|
|Additional Info||IgE and IgD are only indicated in specific clinical circumstances.
In order deliver a cost effective service the departmental policy states that requests for immunoglobulins only should be made in the context of systemic inflammatory illnesses and immunodeficiency. Serum electrophoresis may be added at the validation stage if thought appropriate. We also recommend that requests for Serum Electrophoresis only are made if the identification or exclusion of a paraprotein in the serum (i.e. myeloma, MGUS, etc) is being investigated. Serum Immunoglobulin quantification is then only undertaken if a paraprotein is identified. It is recommended that a urine sample is provided to the laboratory WITH the serum sample to allow identification of free light chain (Bence Jones protein) in the urine if present.|
|Interpretation||Interpret in the context of the age-related reference ranges.
Polyclonal increases in immunoglobulins can be seen in chronic infections, autoimmune diseases, and many tumours cause increases in polyclonal immunoglobulins. Skin, pulmonary and gut diseases are more likely to cause increases in IgA concentrations while systemic infections will increase all immunoglobulins but particularly IgG.|
|Collection Conditions||No restrictions|
|Min. Vol||2 mL|
|Ref. Range (Male)||Age related normal range|
|Ref. Range (Female)||Age related normal range|
|Ref. Range (Paed)|| |
|Ref. Range Notes||See laboratory report for age related ranges:
Adult reference ranges:
IgG = 6 - 16g.L
IgA = 0.8 - 4g/L
IgM = 0.5 - 2g/L|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||7 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||7 days|
|Turnround Comment||Minimum re-test interval = 28 days|
Originally edited by : JHB. Review due on 14/09/2018 14:29:38. Published By AM on 14/09/2017 14:29:38.