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ID:108 Immunoglobulins (IgG, IgA, IgM)
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DescriptionThere are three main immunoglobulin isotypes measured by the Immunology laboratory - IgG, IgA and IgM.
IndicationThe main indication for testing immunoglobulin levels is the investigation of immunodeficiency states. Other indications are lymphoproliferative diseases however a Myeloma screen requires serum and urine electrophoresis.
Additional InfoIgE and IgD are only indicated in specific clinical circumstances. In order deliver a cost effective service the departmental policy states that requests for immunoglobulins only should be made in the context of systemic inflammatory illnesses and immunodeficiency. Serum electrophoresis may be added at the validation stage if thought appropriate. We also recommend that requests for Serum Electrophoresis only are made if the identification or exclusion of a paraprotein in the serum (i.e. myeloma, MGUS, etc) is being investigated. Serum Immunoglobulin quantification is then only undertaken if a paraprotein is identified. It is recommended that a urine sample is provided to the laboratory WITH the serum sample to allow identification of free light chain (Bence Jones protein) in the urine if present.
Concurrent Testsna
Dietary Requirementsna
InterpretationInterpret in the context of the age-related reference ranges. Polyclonal increases in immunoglobulins can be seen in chronic infections, autoimmune diseases, and many tumours cause increases in polyclonal immunoglobulins. Skin, pulmonary and gut diseases are more likely to cause increases in IgA concentrations while systemic infections will increase all immunoglobulins but particularly IgG.

DepartmentClinical Immunology
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol2 mL

Ref. Range (Male)Age related normal range
Ref. Range (Female)Age related normal range
Ref. Range (Paed)
Ref. Range NotesSee laboratory report for age related ranges: Adult reference ranges: IgG = 6 - 16g.L IgA = 0.8 - 4g/L IgM = 0.5 - 2g/L
IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentMinimum re-test interval = 28 days

Originally edited by : JHB. Review due on 14/09/2018 14:29:38. Published By AM on 14/09/2017 14:29:38.