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ID:106 17-hydroxyprogesterone (17 OHP, 17 alphahydroxyprogesterone)
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DescriptionUsed in the investigation of ambiguous genitalia in the newborn infant, diagnosis and monitoring of patients with classical and late-onset congenital adrenal hyperplasia (CAH). 17OH-progesterone should not be requested in infants less than 48 hours old. Urgent assays by arrangement ext 67043, 64717.
IndicationInvestigation of ambiguous genitalia in the newborn, diagnosis and monitoring of CAH patients
Additional InfoSend to: Specialist Laboratory Medicine Block 46 St James hospital Beckett Street Leeds LS9 7TF
Concurrent Testsna
Dietary Requirementsna
Interpretation17OHP is raised in CAH due to 21-hydroxylase deficiency. 21-hydroxylase deficiency is the commonest cause of CAH. Elevated concentrations of 17OHP may be seen in sick individuals as part of the stress response. Although appropriate therapy should always be initiated, confirmatory tests for CAH must be performed afterwards. Monitoring patients is difficult due to intrinsic diurnal rhythms in 17OHP, episodic nature of secretion, and the timing of sample collection in relation to glucocorticoid dose. Daily profiles using several samples during the day may offer a more complete picture of therapeutic control (early morning, mid-day, mid-afternoon and evening). This can be done with either blood or saliva (see saliva entry).

DepartmentSpecialist Laboratory Medicine
SampleBlood
TubeSerum Gel
Tube Picture
Collection ConditionsNo restrictions
Min. Vol1 mL
Freq.Twice Weekly

Ref. Range (Male)<5.0 nmol/L
Ref. Range (Female)<5.0 nmol/L
Ref. Range (Paed)see comment
Ref. Range NotesRef. Range Notes = 5 days M + F < 3.0 nmol/L, = 16 y M + F < 4.0 nmol/L, adult female results may be higher in luteal phase of cycle.
Unitsnmol/L
IP Acute TAT- Contact Laboratory
IP Routine TAT14 days
GP Acute TAT- Contact Laboratory
GP Routine TAT14 days
Turnround CommentNA

Originally edited by : JHB. Review due on 23/01/2020 08:48:18. Published By RB on 23/01/2019 08:48:18.