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ID:1053 Platelet Nucleotides
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DescriptionThe nucleotides ATP and ADP are stored in the dense granules of platelets and are utilised for the initiation/propogation of aggregation. Since they do not participate in any energy-producing reactions of the cell, they are known as the non-metabolic pool. Storage Pool Disease (SPD) is a platelet function defect due to a lack of dense granules. Certain ‘release defects’ result in a reduction of secreted ADP and ATP from the dense granules. Measurement of total and released nucleotides aids the diagnosis of bleeding disorders due to platelet function abnormalities.
IndicationBleeding diatheses where the indication may be due to irregular platelet function.
Additional InfoUsually requested as part of a full platelet function study. This test is only available by specialist request from a Haematology Consultant and should be discussed with a member of the Haemostasis consultant team before arriving into the laboratory. All platelet testing is prearranged with the laboratory before samples are taken to ensure that relevant trained staff are available on the day to process the tests and ensure that we have contact information for the requestor.
Concurrent TestsPlatelet aggregation studies, Platelet glycoproteins, PFA-100
Dietary Requirementsna
InterpretationReduction or imbalance of platelet nucleotides may be indicative of specific platelet disorders, including storage pool or release defects.

DepartmentSpecialist Coagulation
SampleBlood
TubeCoagulation
Tube Picture
Collection ConditionsCitrate x 8 minimum if requested as part of a platelet function analysis. Citrate x 4 if requested in isolation as a follow up test. All samples must be correctly filled.
Min. Vol2 x citrate samples filled to the line.
Freq.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesMale: Total ATP: 25.5 - 68.9 nM/109 plts. Total ADP: 12.8 - 39.7 nM/109 plts Released ATP: 4.1 - 18.9 nM/109 plts Released ADP: 5.3 - 28.5 nM/109 plts Total ATP:ADP Ratio: 1.24 – 2.56 Released ATP:ADP Ratio: 0.43 – 0.79 Female: Total ATP: 25.5 - 68.9 nM/109 plts. Total ADP: 12.8 - 39.7 nM/109 plts Released ATP: 4.1 - 18.9 nM/109 plts Released ADP: 5.3 - 28.5 nM/109 plts Total ATP:ADP Ratio: 1.24 – 2.56 Released ATP:ADP Ratio: 0.43 – 0.79
Unitsnmol/10^9 (platelets
IP Acute TAT4 weeks
IP Routine TAT4 weeks
GP Acute TAT4 weeks
GP Routine TAT4 weeks
Turnround CommentNA

Originally edited by : na. Review due on 22/01/2020 10:06:09. Published By on 22/01/2019 10:06:09.