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ID:105 Hydroxyindole Acetic Acid (5-HIAA - urine)
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Description5-hydroxyindoleacetic acid (5HIAA) is a metabolite of serotonin. Measurement of 5HIAA in urine is used to exclude serotonin-secreting neuroendocrine carcinoid tumours as a cause of current symptoms. Features of carcinoid disease or the carcinoid syndrome include flushing, diarrhoea, wheezing and heart disease. Plasma 5HIAA and whole blood serotonin can also be measured and may offer better sensitivity and specificity for the investigation of possible carcinoid disease.
IndicationInvestigation of possible carcinoid disease. Reference data may not be valid for other indications e.g. investigation of serotonin syndrome.
Additional InfoThe following must be avoided for 12 hours before and during the collection period: Banana, tomato, pineapple, avocado, plum, walnuts, pecans, kiwi, chocolate. Any processed food that may contain the above ingredients. Any health food supplements containing 5-Hydroxytryptophan (extract of Griffonia Simplicifolia seed)
Concurrent Testsna
Dietary RequirementsPlease refer to additional information
InterpretationElevated results may be due to presence of a carcinoid tumour or interference from the diet or 5HTP supplements.

DepartmentSpecialist Laboratory Medicine
Sample24h Urine
Tube24h Acid Urine
Tube Picture
Collection ConditionsAccurately timed collection, dietary advice required before collection. Avoidance of serotonin containing foods necessary. Contact lab before starting urine collection to obtain correct container for this test.
Min. Vol
Freq.Weekly

Ref. Range (Male)<40
Ref. Range (Female)<40
Ref. Range (Paed) Unknown
Ref. Range Notes
Unitsumol/24h
IP Acute TAT- Contact Laboratory
IP Routine TAT10 days
GP Acute TAT- Contact Laboratory
GP Routine TAT10 days
Turnround CommentNA

Originally edited by : TJD. Review due on 15/04/2020 17:09:59. Published By RB on 15/04/2019 17:09:59.