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ID:945 Functional Complement Activity
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DescriptionThese tests measure the functional integrity of the classical (CH100) and alternative (AP100) complement pathways.
IndicationSuspected complement deficiency eg recurrent infections, especially meningococcal (meningitis) infection.
Additional InfoThe sample must be received and frozen within one hour of collection to maintain sample integrity for this functional assay. Please inform the laboratory prior to requesting this test (23540).
Concurrent TestsComplement C3/4
Dietary Requirementsna

InterpretationInvestigations for complement deficiency will only be undertaken upon request (direct or indirect) from consultant immunologists. Complement deficiencies should be investigated using a cascade of tests: Measurement of haemolytic activity (CH100/AP100) and immunochemical measurement of C3 and C4. If impaired activity is detected, immunochemical detection of individual components may be undertaken, follwing consultation with the Clinical Immunologists. If the functional complement tests are normal, testing for individual complement components is rarely needed. If these tests are performed too soon after acute infection the results may be falsely low.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes CH100 392 - 1019 U/mL AP100 75 - 125 %normal reference serum (nrs)
Units - Not Defined -

Other Help:National Laboratory Medicine Handbook

IP Acute TAT- Not Defined -
IP Routine TAT28 days
GP Acute TAT- Not Defined -
GP Routine TAT28 days
Turnround CommentNA
Originally edited by : Anna McHugh. Last edited on 14/09/2018 14:27:08. Published By AM on 14/09/2017 14:27:08.