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ID:912 Orexin (CSF)
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DescriptionInvestigation of narcolepsy and other neurological sleep disturbances. Orexin (also see Hypocretin) is a neurotransmitter that regulates wakefulness and appetite. The most common form of narcolepsy, in which the sufferer briefly loses muscle tone (cataplexy), is caused by a lack of Orexin in the brain.
Indication
Additional InfoN.B. No serum sample required
Concurrent Testsna
Dietary Requirementsna

Interpretation

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes Normal: >200 pg/mL; Intermediate: 100-200 pg/mL; Low: <100 pg/mL; Highly suggestive of narcolepsy/cataplexy: <50 pg/mL. Intermediate and low values are occassionally found in patients with other neurological diseases associated with sleep disturbance
Unitspg/mL

Other Help:National Laboratory Medicine Handbook

IP Acute TATAt least 4 weeks
IP Routine TATAt least 4 weeks
GP Acute TATAt least 4 weeks
GP Routine TATAt least 4 weeks
Turnround CommentSarosh Irani:sarosh.irani@ndcn.ox.ac.uk
Originally edited by : dan carless. Last edited on 17/10/2017. Published By dan carless on 17/10/2017.