|ID:9 ||Alkaline Phosphatase (ALP)||Search Links: General Info : Protocols : Patient Info|
|Description||ALP hydrolyses phosphate esters at alkaline pH. ALP is present as several isoenzymes; liver, bone, placenta, intestines and kidney. Plasma ALP is principally the liver and bone isoenzymes. Liver ALP derives from the biliary canalicular membrane. Bone ALP derives from osteoblasts.|
|Indication||Hepatobiliary disease, bone disease (Paget's, osteomalacia, rickets), calcium disorders and malignancy.|
|Additional Info||Pathology harmony refernce ranges adopted with new method (Feb 2016). CALIPER ref ranges adopted for paeds.Adult: 30 - 130 U/L
Age Female Male
<14 days 82-249 82-249
15 days to 1 yr 122-473 122-473
1 to 10 yrs 142-336 142-336
10 to 13 yrs 128-420 128-420
13 to 15 yrs 55-255 115-471
15 to 17 yrs 49-116 81-333
17 to 18 yrs 43-86 53-149|
|Interpretation||Method measures total ALP activity.
Increased values may originate from liver, bone, placenta, intestines and malignant tissue. HEPATOBILIARY DISEASE: higher levels indicative of cholestasis (intra or extra hepatic). BONE DISEASE: very high levels are often associated with Paget's. PREGNANCY: modest increases occur. GROWTH: modest increases are seen during periods of rapid bone growth in childhood and adolescence.
Decreased values are seen in: malnutrition, kwashiorkor, vit B12 deficiency, magnesium deficiency, zinc deficiency, gross anaemias and after cardiac surgery. Hypophosphatasia is an inherited disorder which in the childhood form is characterised by dental and bone abnormalities.|
|Ref. Range (Male)||30-130|
|Ref. Range (Female)||30-130|
|Ref. Range (Paed)||See note|
|Ref. Range Notes||ALP changes quite markedly throughout life with peaks in childhood and puberty (and pregnancy). For patients ages 0-18yrs the CALIPER reference ranges have been adopted. (See additional information section) Please contact the lab for further information if required.|
|IP Acute TAT||Refer to Website|
|IP Routine TAT||Refer to Website|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||Refer to Website|
Originally edited by : JHB. Last edited on 01/06/2018 11:37:33. Published By Sylvia McLellan on 01/06/2017 11:37:33.