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ID:81 Anti-ENA Antibodies
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DescriptionAutoantibodies to extractable nuclear antigens (ENAs) are associated with certain connective tissue diseases.
IndicationDiagnosis of SLE, Sjorgen's, Mixed Connective Tissue Disease, Polymyositis, Scleroderma.
Additional InfoAnti-ENA antibody tests are now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser. The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab. For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.
Concurrent Testsna
Dietary Requirementsna

InterpretationAnti- Ro and -La antibodies occur in 30-40% of SLE patients and 60% of patients with Sjogren's syndrome. Anti-Sm antibodies are specific for SLE but are found in only 20-30% of patients (usually non-Caucasian patients). Anti-RNP Ab can be associated with mixed connective tissue disease and with systemic sclerosis. Anto-Scl-70 Ab are associated with systemic sclerosis, and anti-Jo-1 Ab are associated with polymyositis/dermatomyositis. Centromere Ab are associated with limited sclerosis.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range NotesAI unit = Antibody Index With the exception of anti-La and anti-Scl-70 Ab a result of 1AI or above is a positive result. For anti-La and anti-Scl-70 Ab a result of 2.5AI or above is positive.
Units - Not Defined -


IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround CommentNA
Originally edited by : JHB. Last edited on 14/09/2018 14:17:46. Published By AM on 14/09/2017 14:17:46.