|ID:81 ||Anti-ENA Antibodies||Search Links: General Info : Protocols : Patient Info|
|Description||Autoantibodies to extractable nuclear antigens (ENAs) are associated with certain connective tissue diseases.|
|Indication||Diagnosis of SLE, Sjorgen's, Mixed Connective Tissue Disease, Polymyositis, Scleroderma.|
|Additional Info||Anti-ENA antibody tests are now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser.
The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab.
For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.|
|Interpretation||Anti- Ro and -La antibodies occur in 30-40% of SLE patients and 60% of patients with Sjogren's syndrome. Anti-Sm antibodies are specific for SLE but are found in only 20-30% of patients (usually non-Caucasian patients). Anti-RNP Ab can be associated with mixed connective tissue disease and with systemic sclerosis. Anto-Scl-70 Ab are associated with systemic sclerosis, and anti-Jo-1 Ab are associated with polymyositis/dermatomyositis. Centromere Ab are associated with limited sclerosis.|
|Ref. Range (Male)|
|Ref. Range (Female)|
|Ref. Range (Paed)|
|Ref. Range Notes||AI unit = Antibody Index With the exception of anti-La and anti-Scl-70 Ab a result of 1AI or above is a positive result. For anti-La and anti-Scl-70 Ab a result of 2.5AI or above is positive.|
|Units|| - Not Defined -|
|IP Acute TAT||- Contact Laboratory|
|IP Routine TAT||7 days|
|GP Acute TAT||- Contact Laboratory|
|GP Routine TAT||7 days|
Originally edited by : JHB. Last edited on 14/09/2018 14:17:46. Published By AM on 14/09/2017 14:17:46.