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ID:75 Anti-DNA antibodies
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DescriptionAnti-double stranded DNA Ab are a highly sensitive and specific diagnostic marker of SLE. They are the most frequently detected autoAb associated with SLE.
IndicationDiagnosis and monitoring of SLE.
Additional InfoAnti-DNA antibody test is now included in the anti-nuclear antibody (ANA) screen performed on the Bioplex 2200, an automated multiplex analyser. The ANA screen can determine autoantibodies against anti-DNA, Ro (60 and 52kDa), La, Sm, Sm/RNP, RNP (68KDa), Scl-70, Jo-1, CENP-B, chromatin and ribosomal P Ab. For each result the ANA screen is reported as either POSITIVE or NEGATIVE, AND a value for the anti-DNA Ab and each of the ENAs is given. The ANA screen is positive if either the DNA Ab and/or one of more ENA Ab specificities are positive.
Concurrent TestsAnti-nuclear Ab (ANA) screen
Dietary RequirementsNA

InterpretationPositive anti-DNA antibodies are found in 70-90% of patients with SLE and tend to correlate with disease activity. Raised levels may also be seen in a small minority of patients with autoimmune hepatitis. A negative dsDNA Ab does not rule out the diagnosis of SLE.

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes10 IU/ml and above is POSITIVE
Units - Not Defined -

IP Acute TAT- Contact Laboratory
IP Routine TAT7 days
GP Acute TAT- Contact Laboratory
GP Routine TAT7 days
Turnround Comment
Originally edited by : BD. Last edited on 14/09/2018 14:17:28. Published By AM on 14/09/2017 14:17:28.