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ID:70 C-Peptide
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DescriptionA component of insulin synthesis which is released from the pancreas when insulin is secreted. Sample must be received in laboratory within 30 minutes of venepunture. A fluoride tube for glucose should also be sent. Insulin assays are provided for the diagnosis of hypoglycaemia and will only be measured in states of hypoglycaemia. Serum samples are recommended for C-peptide analysis as this allows for any follow up tests (e.g. IGF-2, sulphonylureas) to be performed on the same sample. Lithium heparin is acceptable.
IndicationInvestigation of hypoglycaemia.
Additional InfoProteolytic cleavage of pro-insulin prior to secretion produces the mature insulin molecule and the connecting peptide (C-peptide). C-peptide is secreted in equimolar amounts to insulin but fasting concentrations are often higher due to its longer half-life. The C-peptide has no biological activity and is degraded and excreted by the kidneys.
Concurrent TestsGlucose, insulin.
Dietary Requirementsna

InterpretationIncreased in insulinoma and type II diabetes. Decreased in type I diabetes and exogenous insulin administration.

Ref. Range (Male)0 - 5.2
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes
Unitsng/mL


IP Acute TATRefer to Website
IP Routine TATAt least 1 week
GP Acute TATRefer to Website
GP Routine TATRefer to Website
Turnround CommentDr G Wark:gwen.wark@nhs.net
Originally edited by : JHB. Last edited on 22/11/2018 10:40:56. Published By SB on 22/11/2017 10:40:56.