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ID:68 Cortisol
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DescriptionFirst line test for diagnosis of adrenal disorders. Cortisol is subject to a diurnal rhythms. A random cortisol is only useful if it is found to be very high indicating the need for further investigation of Cushing's.
IndicationDiagnosis of Cushing's syndrome, primary (Addison's) and secondary hypoadrenalism. Also monitornig of steroid replacement therapy.
Additional InfoPLEASE NOTE: TEST CAN ONLY BE ADDED TO A SAMPLE WITHIN 6 HOURS OF COLLECTION
Concurrent Testsna
Dietary Requirementsna

InterpretationNormal serum cortisol does NOT exclude adrenal insufficiency. A synacthen test is necessary. Raised serum cortisol must be followed up by dynamic function tests.Diurnal rhythm 100-600 @ 0900h. Cushings disease is excluded by 2400 h cortisol <50nmol/L. Short synacthen test: normal reponse is >600nmol/L at 30 mins post administration.

Ref. Range (Male)100 - 600
Ref. Range (Female)100-600
Ref. Range (Paed)
Ref. Range Notes100-600 at 09:00 hrs. <50 at 24:00 hrs
Unitsnmol/L

Other Help:? Cushing''''''''s
Other Help:Short synacthen test protocol
Other Help:Dexamethasone suppression test protocol

IP Acute TATRefer to Website
IP Routine TATRefer to Website
GP Acute TAT- Contact Laboratory
GP Routine TATRefer to Website
Turnround CommentNA
Originally edited by : JHB. Last edited on 23/05/2017 07:57:03. Published By Sylvia McLellan on 23/05/2016 07:57:03.