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ID:598 Clostridium difficile toxin (CDT) detection
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DescriptionClostridium difficile toxin can cause diarrhoea in a number of at-risk individuals. It is more common in patients treated with antibiotics or antacid, such as proton-pump inhibitors. Our current method uses an EIA-based screening test to detect the presence of Clostridium difficile in the stool using an antigen called Glutamate Dehydrogenase (GDH). Only those samples found positive for GDH will then be screened for the presence of C. difficile toxin using a cell cytotoxin assay
Additional InfoPatients in the community over 65 years, under 2 years (with appropriate underlying condition) and hospital with greater than 3 days in-patient status are tested. Repeat testing of negative samples within 7 days is not usually helpful. If repeat testing is indicated sooner, please contact Microbiology (Ext 23962). Repeat testing of positive samples for Cl.difficile is NOT recommended within 14 days unless symptoms recur following adequate therapy. If repeat testing is indicated sooner, please contact Microbiology (Ext 23962).
Concurrent Testsna
Dietary Requirementsna


Ref. Range (Male)
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Ref. Range Notes
Units - Not Defined -

IP Acute TAT5 days
IP Routine TATSee Turnaround Comment
GP Acute TAT5 days
GP Routine TATSee Turnaround Comment
Turnround CommentPreliminary detection of Glutatmate Dehydrogenase (GDH) by EIA will be reported within 24 hours. Confirmation of toxin production is longer turnaround time.
Originally edited by : Dr M Denton. Last edited on 30/11/2018 13:34:34. Published By K Roberts on 30/11/2017 13:34:34.