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ID:417 Parathyroid Hormone Related Protein (PTHrp)
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DescriptionA form of PTH produced in tumours which is highly bioactive but may not be detectable in routine assays.Blood must be taken into protease inhibitor containing EDTA tubes. Must be taken, separated and frozen within 30 min. It is only available after discussion with the laboratory.
IndicationPlease note - test not available on ICE. Requests must be discussed with duty biochemist first (Ext 26922). If requesting please hand write a request form and mark FOA Duty Biochemist.
Additional InfoIf a patient is hypercalcaemic and has a raised PTHrP they have a 99% chance of having a malignancy (very specific). A low PTHrP however has a close on 50% sensitivity for the diagnosis. If PTHrP is elevated this is the main cause of the hypercalcaemia in the vast majority of these cases. It should be noted that 12- 15% of patients with malignancy also have primary hyperparathyroidism and removal of an adenoma can result in normalisation of the calcium.
Concurrent Testsna
Dietary Requirementsna

Interpretation

Ref. Range (Male)
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes<1.8 pmol/L
Unitspmol/L


IP Acute TAT6 weeks
IP Routine TAT6 weeks
GP Acute TAT6 weeks
GP Routine TAT6 weeks
Turnround CommentDr Allison Chipchase:allison.chipchase@nnuh.nhs.uk
Originally edited by : . Last edited on 17/10/2017. Published By S.Bennett on 17/10/2017.