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ID:399 Imipramine/Desipramine/Lofepramine
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DescriptionThis test is no longer routinely available. Please contact the Duty Biochemist for further discussion if required Tricyclic antidepressant drugs
IndicationTherapeutic drug monitoring (TDM) of tricyclic antidepressant
Additional InfoImipramine and Lofepramine metabolised to desipramine. Desipramine is monitored on patients receiving Lofepramine due to the extensive first pass metabolism of Lofepramine.
Concurrent Testsna
Dietary Requirementsna

InterpretationConcentrations >1000 ug/l associated with serious toxicity. Imipramine plasma half-life is 8-20 hrs. Desipramine half-life is 10-20 hrs.

Ref. Range (Male)See note
Ref. Range (Female)
Ref. Range (Paed)
Ref. Range Notes150 - 250 ug/l (imipramine + desipramine). 80 - 160 ug/l (desipramine alone)
Units - Not Defined -


IP Acute TAT- Contact Laboratory
IP Routine TAT- Contact Laboratory
GP Acute TAT- Contact Laboratory
GP Routine TAT- Contact Laboratory
Turnround CommentNA
Originally edited by : . Last edited on 23/11/2018 16:46:16. Published By on 23/11/2017 16:46:16.